This is Osaka. Tazuna, a high-school student with a knack for mechanics, accepts a certain repair request and visits a university research facility. There, he meets Koyori, a lone girl asleep on a bed. As though being led by something, Tazuna touches her fingertips - and a voice flows into him from a place unknown. “They, who overcome numerous battles, who overcome trials. They, who accept divine revelation. They, who confront themselves, who make sure not to challenge. These are Hand Shakers...” Tazuna is left bewildered as a new world, Ziggurat, lays before him. Within an instant, Tazuna and Koyori are attacked by something. The many Hand Shakers who must confront god stand in the way of Tazuna and Koyori. Laying their own ‘wishes’ on the line... Handshakers--- are the people who come together joining hands, and bear weapons born from the depths of one’s psyche called “Nimrod”. Together they fight. In order to grant one’s wish, many Hand Shakers fight against each other in a competition of power to reach the pinnacle, where they can meet with “god” and defeat this so called “god”. There, waiting at the end…. I will protect her… with these hands.